A noncompetitive antagonist prevents the agonist from producing any effect at a given receptor site . 非竞争性拮抗剂可阻止激动剂在特定受体部位产生任何效应。
2.
The release of neurotransmitter molecules from one neuron and their attachment to receptor sites on another keep a nerve impulse moving 神经递质分子从一个神经原释放后，附着到另一个接受点，令神经冲动保持运动的状态。
3.
So the results indicate that the two mutants have no significant difference in the toxicity of inhibiting mammal neuron sodium channels , and ala20 or ser20 was not the key residue . the two peptide neurontoxins inhibite mammalian voltage - gated sodium channels through a novel mechanism distinct from other known spider toxins such as 5 - actxs , - agatoxins i - vi which banded receptor site 3 to slow the inactive time course of sodium channels . we suggest that hntx - v maybe target the site 1 of sodium channels in a similar manner to - conotoxins and ttx 同时两种海南捕鸟蛛毒素从影响ttx一s钠通道的方式上来看，与其它已知肤类蜘蛛毒素如6一actxs等通过作用于位点3引起延缓钠通道的失活时间存在明显不同，我们推测hntx一iv和iintx一v可能是以一种新的不同于其它蜘蛛毒素的方式来影响钠通道的，而ttx一s钠通道位点1则很有可能便是它们的作用位点，与ttx和林一eonotoxins相似。
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